The world is a complex system, and understanding it scientifically requires advanced computational resources and approaches. Engineers design the most powerful computers on Earth in order to model and simulate physical systems such as global climate, the expansion of the universe, and the behavior of matter at an atomic level. But today, high performance scientific computing means more than just supercomputers running numerical models, expanding to large-scale data analysis, AI and machine learning, visualization, and distributed and heterogeneous hardware systems.

UChicago CS researchers are changing the face of high performance computing (HPC), creating new computing paradigms at scale for understanding physical, biological, social, and ecological systems and answering the most significant questions facing society. Faculty lead efforts to apply the latest AI and data science approaches for scientific discovery, from computational imaging and spectroscopy to bioinformatics, neuroscience, and agriculture. In these areas, as well as in the development and application of new exascale systems such as Aurora, UChicago CS benefits from a strong partnership with Argonne National Laboratory.

Labs & Groups

Globus Labs

Ian Foster, Kyle Chard
Realizing a world in which all research data are reliably, rapidly, and securely accessible, discoverable, and usable.

Large-Scale Systems Group (LSSG)

Andrew A. Chien
Exploring critical systems research questions underlying sustainable, scalable large-scale systems, including cloud, high performance, edge, and mobile/IoT computing.

Chameleon

Kate Keahey, Haryadi Gunawi
A configurable experimental environment for large-scale edge to cloud research.

Center for Translational Data Science

Robert Grossman
A research center developing the discipline of translational data science and applying to advance biology, medicine, healthcare and environmental research.

Related Faculty

Kyle Chard

Kyle Chard

Research Associate Professor of Computer Science
Andrew A. Chien

Andrew A. Chien

William Eckhardt Distinguished Service Professor of Computer Science

Anshu Dubey

Senior Scientist, CASE Affiliate
Todd Dupont

Todd Dupont

Professor Emeritus of Computer Science, Mathematics, and the James Franck Institute
Ian Foster

Ian Foster

Arthur Holly Compton Distinguished Service Professor of Computer Science
Robert Grossman

Robert Grossman

Frederick H. Rawson Distinguished Service Professor in Medicine, Computer Science
Rana Hanocka

Rana Hanocka

Assistant Professor of Computer Science

Kate Keahey

Senior Scientist, CASE Affiliate
Gordon Kindlmann

Gordon Kindlmann

Associate Professor of Computer Science

Rick Stevens

Professor of Computer Science
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Rebecca Willett

Worah Family Professor in the Wallman Society of Fellows, Computer Science, Statistics, and the College

News & Events

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UChicago CS News

Alumni Spotlight: Shama Tirukkala ‘24 is a Fulbright Finalist

Aug 07, 2025
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UChicago CS News

Finding the “Goldilocks” Solution to a Classic Math Problem: A Breakthrough in Numerical Integration

Jul 29, 2025
UChicago CS News

Ten Years of MSCAPP: Where Public Policy Meets Coding

Jul 25, 2025
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UChicago CS News

Moderation at the Crossroads: How Generative AI Platforms Manage Creativity and Content Safety

Jul 21, 2025
UChicago CS News

Can a Doctor’s Notes Reveal When They’re Tired? New Research Illuminates the Hidden Signals of Physician Fatigue—And Raises Questions About AI in Healthcare

Jul 17, 2025
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UChicago CS News

2025 Midwest Machine Learning Symposium Demonstrates Regional Excellence

Jul 16, 2025
UChicago CS News

PhD Candidate Bogdan Stoica Receives Distinguished Artifact Evaluator Award for Championing Reproducibility in Computer Science

Jul 14, 2025
UChicago CS News

Report from GlobusWorld 2025: Going Beyond Data

Jul 10, 2025
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UChicago CS News

University of Chicago PhD Graduates Secure Tenure-Track Faculty Positions Amid a Competitive Job Market

Jun 25, 2025
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UChicago CS News

Democratizing Digital Graphics: An Undergrad’s Unlikely Path To Putting Agency of 3D-Generation in Users’ Hands

Jun 17, 2025
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UChicago CS News

Faculty Spotlight: Get to Know Kexin Pei

Jun 03, 2025
David Cash
UChicago CS News

David Cash Receives 2025 Quantrell Award for Undergraduate Teaching

Jun 02, 2025
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